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Descripción

The active ingredient in senna leaves is called sennoside. This component molecule is converted by microorganisms in the colon into another substance, anthraquinone rhein, which has beneficial effects on stimulating colon activity (accelerating intestinal peristalsis and improving digestion) and increasing fluid secretion. The laxative effect of sennoside and its active metabolite anthraquinone rhein are believed to inhibit the absorption of water and electrolyte by the large intestine, thereby increasing the volume and pressure of intestinal contents. It will stimulate the propulsive tightening movement of the colon. In addition, the stimulating effect on the secretion of active chlorides increases the content of intestinal water and electrolyte. These changes in the transportation of active electrolytes depend on the calcium element on the surface of the slurry. The laxative effect of sennoside is partially regulated by the stimulation of colonic fluid and electrolyte secretion, and this secretion ability is regulated by the stimulation of the endogenous prostaglandin formation process. Sennoside can be prepared as an enema or suppository, or mixed with a stool softener or a block fiber laxative to form a combined laxative.